Plazomicin is effective in a non-human primate pneumonic plague model

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2016
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Abstract
The efficacy of plazomicin for pneumonic plague was evaluated in a non-human primate model. African Green monkeys challenged with a lethal aerosol of Yersinia pestis [median (range) of 98 (15-331) LD50s] received placebo (n=12) or 'humanized' dose regimens (6.25, 12.5 or 25mg/kg every 24h ā€¦
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Authors Mega WM;Doyle-Eisele M;Cass RT;Kostrub CF;Sherwood RL;Metz MA;Cirz RT;;
Journal bioorganic & medicinal chemistry
Year 2016
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/27614915
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine Disease Models animal* dose-response relationship drug chlorocebus aethiops molecular conformation plague / drug therapy* pmid:27614915 doi:10.1016/j.bmc.2016.08.049 william m mega melanie doyle-eisele ryan t cirz sisomicin / analogs & derivatives* sisomicin / chemistry sisomicin / therapeutic use

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