Biological function of unannotated transcription during the early development of Drosophila melanogaster

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ID: 116902
2006
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Abstract
Many animal and plant genomes are transcribed much more extensively than current annotations predict. However, the biological function of these unannotated transcribed regions is largely unknown. Approximately 7% and 23% of the detected transcribed nucleotides during D. melanogaster embryogenesis map to unannotated intergenic and intronic regions, respectively. Based on computational analysis of coordinated transcription, we conservatively estimate that 29% of all unannotated transcribed sequences function as missed or alternative exons of well-characterized protein-coding genes. We estimate that 15.6% of intergenic transcribed regions function as missed or alternative transcription start sites (TSS) used by 11.4% of the expressed protein-coding genes. Identification of P element mutations within or near newly identified 5ā€² exons provides a strategy for mapping previously uncharacterized mutations to their respective genes. Collectively, these data indicate that at least 85% of the fly genome is transcribed and processed into mature transcripts representing at least 30% of the fly genome.
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Authors J Robert Manak;Sujit Dike;Victor Sementchenko;Philipp Kapranov;Frederic Biemar;Jeff Long;Jill Cheng;Ian Bell;Srinka Ghosh;Antonio Piccolboni;Thomas R Gingeras;J Robert Manak;Sujit Dike;Victor Sementchenko;Philipp Kapranov;Frederic Biemar;Jeff Long;Jill Cheng;Ian Bell;Srinka Ghosh;Antonio Piccolboni;Thomas R Gingeras;
Journal nature genetics
Year 2006
DOI doi:10.1038/ng1875
URL
http://dx.doi.org/10.1038%2Fng1875
Keywords
agriculture biomedicine cancer research general animal genetics and genomics human genetics gene function

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