Biological function of unannotated transcription during the early development of Drosophila melanogaster
Clicks: 226
ID: 116902
2006
Many animal and plant genomes are transcribed much more extensively than current annotations predict. However, the biological function of these unannotated transcribed regions is largely unknown. Approximately 7% and 23% of the detected transcribed nucleotides during D. melanogaster embryogenesis map to unannotated intergenic and intronic regions, respectively. Based on computational analysis of coordinated transcription, we conservatively estimate that 29% of all unannotated transcribed sequences function as missed or alternative exons of well-characterized protein-coding genes. We estimate that 15.6% of intergenic transcribed regions function as missed or alternative transcription start sites (TSS) used by 11.4% of the expressed protein-coding genes. Identification of P element mutations within or near newly identified 5′ exons provides a strategy for mapping previously uncharacterized mutations to their respective genes. Collectively, these data indicate that at least 85% of the fly genome is transcribed and processed into mature transcripts representing at least 30% of the fly genome.
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manak2006naturebiological
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| Authors | J Robert Manak;Sujit Dike;Victor Sementchenko;Philipp Kapranov;Frederic Biemar;Jeff Long;Jill Cheng;Ian Bell;Srinka Ghosh;Antonio Piccolboni;Thomas R Gingeras;J Robert Manak;Sujit Dike;Victor Sementchenko;Philipp Kapranov;Frederic Biemar;Jeff Long;Jill Cheng;Ian Bell;Srinka Ghosh;Antonio Piccolboni;Thomas R Gingeras; |
| Journal | nature genetics |
| Year | 2006 |
| DOI | doi:10.1038/ng1875 |
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