A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

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2018
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Abstract
We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We found 61 somatic copy-number alterations (SCN ā€¦
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Authors Berger AC;Korkut A;Kanchi RS;Hegde AM;Lenoir W;Liu W;Liu Y;Fan H;Shen H;Ravikumar V;Rao A;Schultz A;Li X;Sumazin P;Williams C;Mestdagh P;Gunaratne PH;Yau C;Bowlby R;Robertson AG;Tiezzi DG;Wang C;Cherniack AD;Godwin AK;Kuderer NM;Rader JS;Zuna RE;Sood AK;Lazar AJ;Ojesina AI;Adebamowo C;Adebamowo SN;Baggerly KA;Chen TW;Chiu HS;Lefever S;Liu L;MacKenzie K;Orsulic S;Roszik J;Shelley CS;Song Q;Vellano CP;Wentzensen N; ;Weinstein JN;Mills GB;Levine DA;Akbani R;;
Journal cancer cell
Year 2018
DOI DOI not found
URL
https://www.pubmed.gov/29622464/
Keywords
databases National Center for Biotechnology Information NCBI NLM MEDLINE genetic RNA gene expression regulation humans pubmed abstract nih national institutes of health national library of medicine prognosis research support female N.I.H. Extramural Receptors Organ Specificity gene expression profiling genetic predisposition to disease mutation* neoplastic pmid:29622464 pmc5959730 doi:10.1016/j.ccell.2018.03.014 ashton c berger anil korkut rehan akbani breast neoplasms / genetics* dna copy number variations* gene regulatory networks* genital neoplasms female / genetics* long noncoding / genetics estrogen / genetics

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