Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse

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2015
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Acute myeloid leukemia (AML) with an FLT3 internal tandem duplication (FLT3-ITD) mutation is an aggressive hematologic malignancy with a grave prognosis. To identify the mutational spectrum associated with relapse, whole-exome sequencing was performed on 13 matched diagnosis, relapse, and remission …
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Authors Garg M;Nagata Y;Kanojia D;Mayakonda A;Yoshida K;Haridas Keloth S;Zang ZJ;Okuno Y;Shiraishi Y;Chiba K;Tanaka H;Miyano S;Ding LW;Alpermann T;Sun QY;Lin DC;Chien W;Madan V;Liu LZ;Tan KT;Sampath A;Venkatesan S;Inokuchi K;Wakita S;Yamaguchi H;Chng WJ;Kham SK;Yeoh AE;Sanada M;Schiller J;Kreuzer KA;Kornblau SM;Kantarjian HM;Haferlach T;Lill M;Kuo MC;Shih LY;Blau IW;Blau O;Yang H;Ogawa S;Koeffler HP;;
Journal Blood
Year 2015
DOI DOI not found
URL
https://www.pubmed.gov/26438511/
Keywords
leukemia National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female male N.I.H. Extramural Recurrence Multicenter Study Retrospective Studies myeloid fms-like tyrosine kinase 3 / genetics* induction chemotherapy mutation* pmid:26438511 pmc4661172 doi:10.1182/blood-2015-05-646240 manoj garg yasunobu nagata h phillip koeffler chromatin / genetics chromatin / metabolism dna methylation / genetics exome* acute* / drug therapy acute* / genetics acute* / mortality

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