Significance of FLT3-tyrosine kinase domain mutation as a prognostic factor for acute myeloid leukemia

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2019
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The prognostic significance of FLT3-tyrosine kinase domain (TKD) mutations remains unknown. To investigate the prognostic impact of FLT3-TKD, 676 de novo acute myeloid leukemia (AML), we retrospectively analyzed cases and conducted a review of the literature. Of the 676 de novo AML cases, 34 (5.0%) …
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Authors Sakaguchi M;Yamaguchi H;Kuboyama M;Najima Y;Usuki K;Ueki T;Oh I;Mori S;Kawata E;Uoshima N;Kobayashi Y;Kako S;Tajika K;Shono K;Kayamori K;Hagihara M;Kanda J;Uchiyama H;Kuroda J;Uchida N;Kubota Y;Kimura S;Kurosawa S;Date K;Nakajima N;Marumo A;Omori I;Fujiwara Y;Terada K;Yui S;Wakita S;Arai K;Kitano T;Kakihana K;Kanda Y;Ohashi K;Fukuda T;Inokuchi K;;
Journal international journal of hematology
Year 2019
DOI DOI not found
URL
https://www.pubmed.gov/31432396/
Keywords
leukemia National Center for Biotechnology Information NCBI NLM MEDLINE Asia Europe pubmed abstract nih national institutes of health national library of medicine prognosis Retrospective Studies United States Survival Analysis hiroki yamaguchi masahiro sakaguchi koiti inokuchi myeloid fms-like tyrosine kinase 3 / genetics* pmid:31432396 doi:10.1007/s12185-019-02720-z acute / diagnosis* acute / mortality mutation* protein domains / genetics protein-tyrosine kinases / genetics tandem repeat sequences

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