Linking binge alcohol-induced neurodamage to brain edema and potential aquaporin-4 upregulation: evidence in rat organotypic brain slice cultures and in vivo

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ID: 112504
2009
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Abstract
Brain edema and derived oxidative stress potentially are critical events in the hippocampal-entorhinal cortical (HEC) neurodegeneration caused by binge alcohol (ethanol) intoxication and withdrawal in adult rats. Edema's role is based on findings that furosemide diuretic antagonizes binge alcohol-de ā€¦
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Authors Sripathirathan K;Brown J;Neafsey EJ;Collins MA;;
Journal journal of neurotrauma
Year 2009
DOI DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/19236167
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't N.I.H. Extramural Rats Sprague-Dawley dentate gyrus / pathology diuretics / pharmacology entorhinal cortex / pathology organ culture techniques blotting western pmid:19236167 pmc2848832 doi:10.1089/neu.2008.0682 kumar sripathirathan james brown michael a collins acetazolamide / pharmacology alcohol drinking / metabolism* alcohol drinking / pathology* antioxidants / pharmacology aquaporin 4 / metabolism* brain edema / metabolism* brain edema / pathology* chromans / pharmacology dentate gyrus / metabolism entorhinal cortex / metabolism furosemide / pharmacology nerve degeneration / metabolism nerve degeneration / pathology oxidative stress / drug effects sulfonamides / pharmacology torsemide up-regulation / physiology water / metabolism

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