Acute ethanol administration oxidatively damages and depletes mitochondrial dna in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants

Clicks: 383
ID: 112116
2001
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Abstract
Ethanol metabolism causes oxidative stress and lipid peroxidation not only in liver but also in extra-hepatic tissues. Ethanol administration has been shown to cause oxidative degradation and depletion of hepatic mitochondrial DNA (mtDNA) in rodents, but its in vivo effects on the mtDNA of extra-hep ā€¦
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Authors Mansouri A;Demeilliers C;Amsellem S;Pessayre D;Fromenty B;;
Journal the journal of pharmacology and experimental therapeutics
Year 2001
DOI DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/11454938
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male Ethanol / toxicity* DNA inbred icr brain / drug effects liver / drug effects blotting pmid:11454938 a mansouri c demeilliers b fromenty antioxidants / pharmacology* southern central nervous system depressants / toxicity* mitochondrial / drug effects* fomepizole melatonin / pharmacology mitochondria / drug effects* mitochondria heart / drug effects muscle / drug effects oxidants / toxicity pyrazoles / pharmacology thymidine / metabolism ubiquinone / pharmacology vitamin e / pharmacology

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