Pioglitazone improves insulin action and normalizes menstrual cycles in a majority of prenatally androgenized female rhesus monkeys

Clicks: 331
ID: 111799
1970
Insulin resistance plays a mechanistic role in maintaining anovulation in a majority of PA female monkeys.
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Authors Zhou R;Bruns CM;Bird IM;Kemnitz JW;Goodfriend TL;Dumesic DA;Abbott DH;;
Journal reproductive toxicology (elmsford, ny)
Year 1970
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/17306503
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine research support female N.I.H. Extramural david h abbott luteinizing hormone / blood Fatty Acids Nonesterified / blood estradiol / blood follicle stimulating hormone / blood polycystic ovary syndrome / blood macaca mulatta rao zhou area under curve dehydroepiandrosterone / blood pmid:17306503 pmc2705750 doi:10.1016/j.reprotox.2006.12.009 cristin m bruns androstenedione / blood body weight / drug effects chorionic gonadotropin / pharmacology glucose tolerance test glycated hemoglobin a / metabolism gonadotropin-releasing hormone / pharmacology hypoglycemic agents / pharmacokinetics hypoglycemic agents / pharmacology insulin / blood* insulin resistance / physiology* luteinizing hormone / drug effects menstrual cycle / drug effects* menstrual cycle / physiology ovulation / drug effects pioglitazone polycystic ovary syndrome / physiopathology polycystic ovary syndrome / prevention & control progesterone / analogs & derivatives progesterone / biosynthesis progesterone / blood testosterone propionate / blood thiazolidinediones / pharmacokinetics thiazolidinediones / pharmacology*

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