Role of phosphatase and tensin homolog in pathogenesis of ameloblastoma: An immunohistochemical study

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2020
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Background: Altered molecular signaling pathways in ameloblastoma have been identified to play a pivotal role in the mechanism of oncogenesis, differentiation, and tumor progression. Phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway is one of the signaling pathways that are associated with the pathogenesis of ameloblastoma. Phosphatase and tensin homolog (PTEN) controls cell migration and proliferation. It monitors the level of the Akt and maintains cellular integrity. The present study was aimed to study the immunoexpression of PTEN in ameloblastoma to understand its role in the pathogenesis of ameloblastoma. Materials and Methods: Twenty cases of ameloblastoma and ten cases of normal tooth germ were subjected to immunohistochemical staining against PTEN. Results: Strong PTEN immunopositivity was seen in the tooth germs, while weak positivity was seen in the ameloblastoma. The immunoscore for PTEN was calculated by adding the percentage score and the intensity score. Seventeen cases showed the reduced PTEN expression in the epithelial component of ameloblastoma. The unpaired t-test showed a statistically significant difference in the mean PTEN immunoscore in tooth germ and ameloblastoma. Conclusion: The study showed reduced PTEN immunoreactivity, which plays a role in the pathogenesis of ameloblastoma, through Akt pathway.
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narayan2020journalrole Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Narayan;Bhaskar Narayan;Aadithya B Urs;Jeyaseelan Augustine;Hanspal Singh;
Journal journal of cancer research and therapeutics
Year 2020
DOI 0973-1482
URL
http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2020;volume=16;issue=3;spage=513;epage=516;aulast=Narayan;type=0
Keywords
Online E-Journal full-text electronic free access open access J Can Res Ther online submissionameloblastoma immunohistochemistry phosphatase and tensin homolog tooth germs

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