A Novel, One-Step Palladium and Phenylsilane Activated Amidation from Allyl Ester on Solid Support

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2008
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Abstract
The direct conversion of solid-supported carboxylic acid allyl esters to carboxamides through the use of phenylsilane and catalytic Pd(PPh3)4 under mild reaction conditions is reported. The use of this methodology for the generation of a 48 compound solid-phase array is described herein.
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Authors Ruan, Zheming;Van Kirk, Katy;Cooper, Christopher B.;Lawrence, R. Michael;Ruan, Zheming;Van Kirk, Katy;Cooper, Christopher B.;Lawrence, R. Michael;
Journal organic chemistry international
Year 2008
DOI 10.1155/2008/696090
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