The Fight Against Obesity Escalates: New Drugs on the Horizon and Metabolic Implications.

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ID: 107783
2020
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Abstract
There is currently a steep rise in the global prevalence of obesity. Pharmaceutical therapy is a valuable component of conservative obesity therapy. Herein, medications currently in the phase of preclinical or clinical testing are reviewed, along with an overview of the mechanisms that regulate energy intake and expenditure. In addition, the current and potential future directions of obesity drug therapy are discussed.Although the current arsenal of obesity pharmacotherapy is limited, a considerable number of agents that exert their actions through a variety of pharmacodynamic targets and mechanisms are in the pipeline. This expansion shapes a potential near future of obesity conservative management, characterized by tailored combined therapeutic regimens, targeting not only weight loss but also improved overall health outcomes. The progress regarding the elucidation of the mechanisms which regulate the bodily energy equilibrium has led to medications which mimic hormonal adaptations that follow bariatric surgery, in the quest for a "Medical bypass." These, combined with agents which could increase energy expenditure, point to a brilliant future in the conservative treatment of obesity.
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tsilingiris2020thecurrent Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Tsilingiris, Dimitrios;Liatis, Stavros;Dalamaga, Maria;Kokkinos, Alexander;
Journal current obesity reports
Year 2020
DOI 10.1007/s13679-020-00378-x
URL
Keywords
obesity energy expenditure weight loss appetite gut peptides medical bypass semaglutide

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