Assembly and antifungal effect of a new fluconazole-carrier nanosystem.

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ID: 107123
2020
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Abstract
To assemble, characterize and assess the antifungal effects of a new fluconazole (FLZ)-carrier nanosystem. The nanosystem was prepared by loading FLZ on chitosan (CS)-coated iron oxide nanoparticles (IONPs). Antifungal effects were evaluated on planktonic cells (by minimum inhibitory concentration determination) and on biofilms (by quantification of cultivable cells, total biomass, metabolism and extracellular matrix) of and . Characterization results ratified the formation of a nanosystem (<320 nm) with FLZ successfully embedded. IONPs-CS-FLZ nanosystem reduced minimum inhibitory concentration values and, in general, showed similar antibiofilm effects compared with FLZ alone. IONPs-CS-FLZ nanosystem was more effective than FLZ mainly in inhibiting planktonic cells. This nanocarrier has potential to fight fungal infections.
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de-lima2020assemblyfuture Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors de Lima, Taynara Mt;Arias, Laís S;Afanaci, Letícia F;Ferraresse, Raphael Fb;de S Neto, Francisco N;de Lima, Bruno Hr;Straioto, Fabiana G;de Camargo, Emerson R;Pessan, Juliano P;Monteiro, Douglas R;
Journal future microbiology
Year 2020
DOI 10.2217/fmb-2019-0182
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Keywords
chitosan iron oxide nanoparticles biofilms fluconazole candida

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