Synthesis and investigation of antimicrobial activities of nitrofurazone analogues containing hydrazide-hydrazone moiety.
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2017
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In this research we synthesized and tested for antimicrobial activity 21 nitrofurazone analogues. The compounds we obtained were identified on the basis of H NMR and C NMR spectroscopy. The screening of antimicrobial properties of synthesized compounds revealed a wide spectrum of antimicrobial activity. Compounds , , -, and - showed very high bactericidal effect towards spp. ATTC and spp. ATTC (MIC = 0.002-7.81 µg/ml and MBC = 0.002-31.25 µg/ml). The levels of activity of several compounds were far better than those of nitrofurantoin, ciprofloxacin or cefuroxime.
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| Authors | Popiołek, Łukasz;Biernasiuk, Anna; |
| Journal | saudi pharmaceutical journal : spj : the official publication of the saudi pharmaceutical society |
| Year | 2017 |
| DOI | 10.1016/j.jsps.2017.05.006 |
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