A study of Pt(II)-phenanthroline complex interactions with double-stranded and G-quadruplex DNA by ESI-MS, circular dichroism, and computational docking.

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2020
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Abstract
The binding interactions of a series of square-planar platinum(II)-phenanthroline complexes of the type [Pt(P)(A)] [where P = variously methyl-substituted 1,10-phenanthroline (phen) and A = ethane-1,2-diamine (en)] were assessed with a G-quadruplex DNA (5'-TTG GGG GT-3', G4DNA) and a double-stranded DNA (5'-CGC GAA TTC GCG-3', dsDNA) sequence by ESI-MS. The results indicate a strong correlation between G4DNA affinity and increasing phenanthroline methyl substitution. Circular dichroism (CD) spectroscopy and molecular docking studies also support the finding that increased substitution of the phenanthroline ligand increased selectivity for G4DNA. ESI-MS was used to probe the interaction of a range of square-planar Pt(II)-phenanthroline complexes with double-stranded and G-quadruplex DNA.
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Authors Ang, Dale L;Kelso, Celine;Beck, Jennifer L;Ralph, Stephen F;Harman, David G;Aldrich-Wright, Janice R;
Journal journal of biological inorganic chemistry : jbic : a publication of the society of biological inorganic chemistry
Year 2020
DOI 10.1007/s00775-020-01773-4
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Keywords
computational chemistry Docking Mass spectrometry platinum anticancer drug g-quadruplex binding affinity

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