Discovery and Biosynthesis of Neoenterocins Indicate a Skeleton Rearrangement of Enterocin.

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ID: 101064
2019
Two polyketides neoenterocins A () and B (), featuring a neighboring dicarbonyl motif and a furan-containing 5/6 ring system, were isolated from the enterocin producer sp. SCSIO 11863. Heterologous expression, gene disruptions, and isotope feeding experiments indicated that and were derived from the enterocin biosynthetic gene cluster. However, was demonstrated as an artifact from enterocin via a unique skeleton rearrangement.
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Authors Zheng, Liujuan;Jiang, Xiaodong;Zhang, Qingbo;Zhu, Yiguang;Zhang, Haibo;Zhang, Wenjun;Saurav, Kumar;Liu, Jinsong;Zhang, Changsheng;
Journal Organic letters
Year 2019
DOI 10.1021/acs.orglett.9b03460
URL
Keywords
actinobacteria lc-hrms natural product biosynthetic gene clusters (bgcs) cyclic dipeptides (2,5-diketopiperazines, dkps) global natural product social networking (gnps) quorum sensing inhibition (qsi)

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