Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila.
Clicks: 228
ID: 100836
2020
High-sugar diets cause thirst, obesity, and metabolic dysregulation, leading to diseases including type 2 diabetes and shortened lifespan. However, the impact of obesity and water imbalance on health and survival is complex and difficult to disentangle. Here, we show that high sugar induces dehydration in adult Drosophila, and water supplementation fully rescues their lifespan. Conversely, the metabolic defects are water-independent, showing uncoupling between sugar-induced obesity and insulin resistance with reduced survival in vivo. High-sugar diets promote accumulation of uric acid, an end-product of purine catabolism, and the formation of renal stones, a process aggravated by dehydration and physiological acidification. Importantly, regulating uric acid production impacts on lifespan in a water-dependent manner. Furthermore, metabolomics analysis in a human cohort reveals that dietary sugar intake strongly predicts circulating purine levels. Our model explains the pathophysiology of high-sugar diets independently of obesity and insulin resistance and highlights purine metabolism as a pro-longevity target.
| Reference Key |
van-dam2020sugarinducedcell
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | van Dam, Esther;van Leeuwen, Lucie A G;Dos Santos, Eliano;James, Joel;Best, Lena;Lennicke, Claudia;Vincent, Alec J;Marinos, Georgios;Foley, Andrea;Buricova, Marcela;Mokochinski, Joao B;Kramer, Holger B;Lieb, Wolfgang;Laudes, Matthias;Franke, Andre;Kaleta, Christoph;Cochemé, Helena M; |
| Journal | cell metabolism |
| Year | 2020 |
| DOI | S1550-4131(20)30075-9 |
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.